16.313 artigos
In mice with chemically induced liver scarring, the NAMPT inhibitor FK866 lowered liver injury, fibrosis markers, and inflammation, pointing to a new target.
HyperProbe1.1 images glioma tissue in about 30 seconds, mapping hemoglobin, cytochromes, and NADH/FAD without contrast agents, a step toward real-time neuronavigation.
A fully oral blend of pterostilbene, silybin, nicotinamide riboside and captopril helped 90% of mice survive lethal X-rays while sparing tumor radiotherapy effects.
A 2026 review says high-dose taurine prevented stroke-like episodes in 60% of MELAS patients, while sonlicromanol and gene editing advance.
A narrative review explores how age-related CHIP mutations in blood stem cells, and possibly in vessel walls, drive inflammation and cardiovascular risk.
A new review explains why TET2 loss fuels age-related blood clones and inflammation yet can strengthen engineered CAR-T cells, depending on cell type and context.
A JCI commentary explains how DNMT3A drives DNA repair in macrophages after efferocytosis and why clonal hematopoiesis mutations may impair plaque healing.
Boosting the antioxidant enzyme GPX4 in retinal ganglion cells promoted optic nerve regrowth, cell survival, and vision in mouse optic nerve injury and glaucoma models.
A review lays out how to define and track bacterial strains in FMT and live biotherapeutics, from culturing to metagenomics, to link engraftment with clinical outcomes.
Uma revisão sistemática de 33 estudos (2.112 pacientes) conclui que as terapias voltadas ao microbioma intestinal são seguras e estão associadas à redução das lesões de acne, embora não tenham se mostrado claramente melhores do que os controles.
Um teste comparativo direto mostra que a reprogramação com mRNA-LNP, livre de vírus, equivale às iPSCs e aos cardiomiócitos obtidos com o vírus Sendai, alcançando marcos importantes em menos passagens.
A IA generativa criou um novo inibidor de PKMYT1 e o transformou em um degradador oral que reduziu tumores em modelos de xenoenxerto em camundongos.
