14,760 articles
The therapeutic landscape for ATTR-CM is evolving rapidly, with new targeted agents challenging how clinicians choose and sequence treatment.
Transplanting aged human gut microbiota into pigs dismantles intestinal tight junctions and reshapes plasma metabolites, revealing microbial drivers of age-related gut decline.
A prospective trial shows sotatercept reduces right ventricular afterload and remodels heart mechanics, improving functional reserve in pulmonary arterial hypertension.
A molecule secreted by a human gut bacterium reduces visceral fat in mice, pointing to a new microbiome-based strategy for treating obesity.
A newly discovered iron-MSRA pathway triggers the fat loss seen in cancer cachexia. Deleting MSRA in mice reduces wasting and prolongs survival.
A novel IL-21 cytokine mimic recruits CD4 T cells to make KRAS inhibition produce durable remissions in pancreatic cancer — a historically lethal disease.
A large proteomics study links menopause-driven protein shifts to accelerated brain aging and higher dementia risk in older women.
Adipocytes do far more than store energy — new evidence shows they actively fight pathogens and regulate immunity, with major implications for aging.
A new Nature Aging review identifies the distinct molecular signatures that define cellular senescence, opening doors to better senolytics and aging biomarkers.
Perimenopausal women show measurably lower brain creatine than younger adults, with regional deficits tied to concentration difficulties and estradiol drops.
FGF21 activates the Nrf2/GPX4 pathway to suppress ferroptosis after TBI, cutting oxidative damage and improving neurological recovery in mice.
A mouse study overturns the assumption that liver-derived FGF21 drives fasting metabolism, revealing its true role: directing protein appetite after food deprivation.
