Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
3,175 articles
HyperProbe1.1 images glioma tissue in about 30 seconds, mapping hemoglobin, cytochromes, and NADH/FAD without contrast agents, a step toward real-time neuronavigation.
A new review explains why TET2 loss fuels age-related blood clones and inflammation yet can strengthen engineered CAR-T cells, depending on cell type and context.
Higher lifetime nitrogen dioxide exposure tracked with an 84-day increase in teens’ epigenetic age, but most pollution comparisons showed no association.
A new review maps how gut microbial metabolites like SCFAs, bile acids and tryptophan derivatives drive inflammaging, and how they might be harnessed as therapies.
A six-month trial found better artery function with NOVOS Core, but participant losses, age differences, and industry funding warrant caution.
A study of more than 41,000 dogs links canine and human mortality patterns, offering clues—not proof—about shared influences on longevity.
In 904 middle-aged adults, organ-specific aging clocks showed uneven aging across the body. Cardiovascular, bone, metabolic and brain ages predicted heart events better than chronological age.
Organ-specific proteomic clocks suggest alcohol slows aging in some organs. A new Perspective explains why these findings conflict and why caution is needed.
UC Berkeley researchers link tau buildup in the frontal cortex to disrupted slow waves in deep sleep and weaker overnight memory consolidation.
Muna's once-daily pill MNA-001 shifted age-linked brain markers in elderly volunteers toward younger levels, though clinical benefit remains unproven.
A review links iron buildup, lipid peroxidation and failing antioxidant defenses to Alzheimer's, Parkinson's, Huntington's and ALS, and surveys possible treatments.
A review proposes that aging cells drift toward a scar-forming mesenchymal state, and that reprogramming or TGF-β blockade may reverse it.
