Longevity Pulse — Science-Backed Insights for a Longer, Healthier Life

Autoimmune & Arthritis

Itaconate, an immune cell metabolite, rewires inflammation by chemically tagging key proteins

Macrophages make itaconate, which tags inflammatory proteins like NLRP3, STING1 and GPX4. This review maps how it controls inflammation and cell death.

Metabolic Health

GLP-1 Drugs Show Mixed Results for Reducing Pancreatic Fat

A six-study review finds promise but inconsistent human evidence that GLP-1 drugs reduce pancreatic fat, with no direct human data for semaglutide.

Heart Health

Off-Pump Bypass Shows No Clear Overall Advantage in Frail Older Adults

In 508 older adults with frailty, bypass techniques showed no significant difference in major complications, but off-pump surgery had fewer infections.

Heart Health

Semaglutide Lowers Heart Filling Pressures in Patients With Obesity and HFpEF

A randomized trial found semaglutide reduced heart filling pressures, with normal readings at rest and exercise in over half of treated patients.

Nov 10, 2026 0

Brain Health

Low-dose rapamycin boosts brain blood flow in people at genetic risk for Alzheimer's

A four-week low-dose rapamycin trial improved brain blood flow in middle-aged APOE4 carriers, with women showing the strongest benefit, years before symptoms.

Press Release

Nov 9, 2026 0

Regenerative Medicine

New Framework Challenges Claims That Cosmetic Treatments Regenerate Skin

Smoother skin does not necessarily mean regenerated skin. A new framework separates cosmetic improvement from restoration of skin biology.

Nov 9, 2026 0

Nutrition & Diet

Full-Fat Dairy Leaves Weight and Cholesterol Unchanged in a Small 12-Week Trial

A trial in 74 adults challenges assumptions about full-fat dairy, but its short duration and differing calorie targets limit the conclusions.

Press Release

Nov 7, 2026 0

Nutrition & Diet

Higher Methyl-Donor Nutrient Intake Tracks With Lower Frailty Odds

In 13,528 U.S. adults, higher methyl-donor nutrient scores tracked with lower frailty odds. Oxidative stress may help explain the association.

Nov 6, 2026 0

Autoimmune & Arthritis

UK Lupus Study Finds Unequal Responses After Treatment Escalation

Only 23% met major response criteria after stronger lupus treatment. Black patients had greater initial disease burden and lower observed response.

Nov 6, 2026 0

Supplements

NAD+ Supplements Alone Fall Short Against Age-Related Muscle Loss

A review finds NAD+ precursors have not improved muscle mass or strength in older adults, while exercise combinations remain unproven.

Review

Nov 4, 2026 0

Regenerative Medicine

Injectable Gel Helps a Repair Protein Rebuild Injured Muscle in Preclinical Study

A gel released Cripto for up to 28 days and improved muscle repair in a preclinical model, while a single protein injection did not.

Clinical Tutorials Videos Listen to all View all

Nov 3, 2026 0

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How Playing the Symphony of Longevity Will Enable Us to Live Young for a Lifetime — Jeffrey Gladden, MD, FACC

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Tutorials

SupplementsIntermediate

Taurine's Supply Chain: Synthesis, Transport, and the Aging Question

Nov 11, 2026

SupplementsBeginner

Taurine and Aging: What This Amino Acid-Like Compound Does and Whether to Supplement

Nov 10, 2026

Metabolic HealthAdvanced

Selective Insulin Resistance to Scar Tissue: The Molecular Biology of MASLD in an Aging Liver

Metabolic HealthIntermediate

Nov 9, 2026

Why the Liver Fills With Fat: The Mechanisms Behind MASLD and Aging

Nov 8, 2026

Metabolic HealthBeginner

Your Liver Through the Decades: Understanding Fatty Liver Disease

Nov 7, 2026

SupplementsAdvanced

Creatine Kinase Thermodynamics, Compartmentation, and the Limits of the Phosphagen Buffer

Nov 6, 2026

SupplementsIntermediate

Inside the Phosphagen System: How Creatine Kinase Keeps Muscle Power Steady

Nov 5, 2026

SupplementsBeginner

Creatine: Your Muscles' Emergency Fuel Reserve

Nov 4, 2026

Cancer ResearchAdvanced

Reading the p53 Code: Target Selection, Clonal Competition, and Where the Aging Tradeoff Holds

Cancer ResearchIntermediate

Nov 3, 2026

Pulses, Feedback, and Clones: How p53 Balances Cancer Protection Against Aging

Nov 2, 2026

Cancer ResearchBeginner

p53: The Cell's Guardian and the Price of Protection

Exercise & FitnessAdvanced

Nov 1, 2026

The Oxygen Cascade Under Load: Stroke Volume, Mitochondria, and the Mortality Signal in VO2 Max

Exercise & FitnessIntermediate

Oct 31, 2026

Inside the Oxygen Pipeline: What Actually Limits Your VO2 Max

Exercise & FitnessBeginner

Oct 30, 2026

VO2 Max for Beginners: How Your Body Turns Air Into Energy

Oct 29, 2026

SupplementsAdvanced

Why Selenium Doesn't Scale: Sec Supply Chains, GPX4 Chemistry, and the Limits of Repletion