Longevity Pulse — Science-Backed Insights for a Longer, Healthier Life

Metformin Slows Molecular Aging in Human Cells as Rapamycin Shows Limited Effects

November 2, 2026

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Latest Summaries

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Gut & Microbiome

A Gut Bacterial Lipid Helps Muscle Mitochondria Adapt to a Western Diet in Mice

A bacterial lipid improved muscle energy metabolism and preserved muscle fiber size in male mice. Human benefits remain untested.

Research Paper

Nov 2, 2026 0

Supplements

Shen-Qi Paste Shows Promise for Preserving Muscle in Dialysis Patients

A 12-week trial found better muscle mass with Shen-Qi Paste, but no clear mobility benefit. Safety details were missing from the abstract.

Research Paper

Oct 31, 2026 0

Regenerative Medicine

Fatty-acid siRNA silences the muscle-wasting gene myostatin for months in mice

A chemically engineered lipid-linked siRNA shut down myostatin in mouse muscle and heart for up to 20 weeks, building muscle and grip strength without observed toxicity.

Research Paper

Oct 31, 2026 0

Cancer Research

Arginine Restores CAR T Cell Function After Heat Stress in Experiments

Fever may weaken cancer-fighting CAR T cells. Arginine restored their function in experiments, but benefits for patients remain unproven.

Research Paper

Oct 31, 2026 0

Metabolic Health

Orforglipron Pill Delivers Up to 8.7% Average Weight Loss in Japanese Obesity Trial

A 72-week trial found oral orforglipron reduced weight more than placebo. The highest dose did not deliver the greatest average loss.

Research Paper

Oct 31, 2026 0

Nutrition & Diet

Probiotics Add Little to Weight Loss During Calorie Restriction

A review of 19 trials found probiotics added no clear weight-loss benefit to calorie restriction, despite a small reduction in fat mass.

Research Paper

Oct 31, 2026 0

Exercise & Fitness

Four Weeks of Aerobic Training Reshapes Gut Bacteria in Middle-Aged Mice

Aerobic training changed gut microbial composition in middle-aged male mice, but whether those changes drive fitness benefits remains unclear.

Research Paper

Oct 30, 2026 0

Metabolic Health

Nearly Two-Thirds Discontinue Wegovy Within a Year in a Large Israeli Study

Among 34,309 adults starting Wegovy, estimated discontinuation reached 67.6% at one year. Early refill patterns may help flag patients needing support.

Research Paper

Oct 30, 2026 0

Hormones

Statins May Help Build Bone After Menopause Through a Stem Cell Pathway

Statin use tracked with slower bone loss after menopause, while experiments revealed how atorvastatin may support bone formation when estrogen is low.

Research Paper

Oct 30, 2026 0

Autoimmune & Arthritis

Knee artery embolization works equally well with an antibiotic or permanent microspheres in a 12-month trial

In a 60-patient randomized trial, blocking knee blood vessels cut osteoarthritis pain by about half for a year, whether done with imipenem/cilastatin or microspheres.

Research Paper

Oct 29, 2026 0