Latest breakthroughs in cancer research, treatment, and prevention
1,100 articles
A bacterium from a Japanese tree frog's gut cleared every colon tumor in mice after one IV dose, outperforming anti-PD-L1 and doxorubicin in the model.
A new ZDHHC2 inhibitor, TTZ1, restores ACSL4 and triggers ferroptosis, re-sensitizing resistant prostate tumors to enzalutamide in cell and mouse models.
In ferroptosis-sensitive cancer cells, nuclear actin filaments form as cells acidify, and alkaline conditions block them. They appear to be a side effect of ferroptosis, not a cause.
A CRISPR screen shows riboflavin stabilizes FSP1, a shield against ferroptosis. The riboflavin analog roseoflavin disables it and sensitizes cancer cells to ferroptosis.
Across 12 mouse diet models, anti-PD-1 response varied with diet but showed no significant association with metabolic measures. Separately, L. johnsonii plus an obesogenic diet promoted tumor regression in germ-free mice.
A Japanese phase I-II trial pairs antibiotics and donor stool transplant with checkpoint inhibitors in advanced esophageal and gastric cancer.
RIKEN researchers use the carbon monoxide that tumor cells make to trigger a palladium catalyst that builds toxic drugs inside the cancer cells, sparing healthy ones.
An antibody against myostatin, the muscle-growth brake, preserved bone, built muscle and cut bone tumor burden in breast cancer mouse models.
A CA Cancer J Clin review shows how ESR1, PIK3CA and RB1 changes, RNA subtypes and patient preferences now guide each step of HR-positive/HER2-negative metastatic breast cancer care.
Go below the pulse-and-feedback model to p53's target-gene choices, the mouse genetics behind the aging cost, and the clonal selection that lets a protective system seed later cancers. Includes an honest account of what is and isn't shown in humans.
Blocking a tumor enzyme boosted immune-cell killing in mice and patient-derived tumor models, pointing to a potential cancer immunotherapy target.
p53 is wired as a fast feedback circuit whose timing, not just its level, decides a cell's fate. See how that wiring explains both cancer protection and the cost to aging tissues.
