Supplements, peptides, nootropics, and bioactive compounds for health optimization
233 articles
A molecular-level look at the creatine kinase equilibrium, mitochondrial coupling, what happens when phosphocreatine runs out, and how transporter biology sets the ceiling on supplementation.
Go beyond 'creatine fuels sprints' to the creatine kinase reaction, the phosphocreatine shuttle, how muscle takes up creatine, and what that means for dosing and lab results.
Learn how your muscles power the first few seconds of all-out effort, what creatine has to do with it, and how to use it sensibly.
A review finds NAD+ precursors have not improved muscle mass or strength in older adults, while exercise combinations remain unproven.
Selenium is built into proteins through a rewired genetic code, and not every selenoprotein gets equal priority when supply runs short. See how the key ones work and what the aging-related evidence supports.
Huberman outlines a goal-driven supplement strategy, putting diet and behavior first. The episode description offers guidance, not clinical proof.
NR protected skin flaps in rats and boosted cellular recycling, pointing to a possible tissue repair application—not proven benefits in humans.
Andrew Huberman explains how to build a supplement protocol around your needs, diet and budget, and why behavior and nutrition come first.
A narrative review proposes multivitamins, protein, creatine, HMB, vitamin D, omega-3s, fiber and probiotics to offset muscle and nutrient losses on GLP-1 drugs.
NMN improved hormone and metabolic problems in rats with PCOS, revealing a possible treatment target—not evidence of benefits in women.
A review suggests NAC can protect stressed insulin-producing cells, but excessive antioxidant exposure may interfere with their normal function.
NMN and NR can raise blood NAD+, but longer, healthier lives remain unproven. Independent testing matters more than anti-aging promises.
