New Fisetin-Derived Senolytics Outperform the Original and Extend Healthspan in Mice

New Fisetin-Derived Senolytics Outperform the Original and Extend Healthspan in Mice

Research Paper
October 7, 2026

Get Longevity Research Delivered Weekly

Join thousands of health professionals and curious minds. No spam, ever.

Enter your email to subscribe:

Your AI Longevity Team

Categories

Latest Summaries

Fresh from academic journals, YouTube, podcasts, and other sources

View all
New RNA Drugs Cut Triglycerides by Up to 80% — Rewriting Heart Risk Treatment
Heart Health

New RNA Drugs Cut Triglycerides by Up to 80% — Rewriting Heart Risk Treatment

A comprehensive review of emerging gene-silencing therapies — ASOs, siRNA, and FGF21 analogs — that slash triglycerides far beyond what statins or fibrates can achieve.

Research Paper
Oct 7, 2026 0
Bystander T Cells in Tumors Emerge as Promising Immunotherapy Targets
Cancer Research

Bystander T Cells in Tumors Emerge as Promising Immunotherapy Targets

A new mouse protocol reveals how virus-specific bystander CD8+ T cells infiltrate tumors and behave differently from exhausted tumor-specific T cells.

Research Paper
Oct 7, 2026 0
Long-Lived Killifish Preserve Brain Mitochondria Through Stronger Antioxidant Defenses
Brain Health

Long-Lived Killifish Preserve Brain Mitochondria Through Stronger Antioxidant Defenses

Killifish strains with longer lifespans maintain brain mitochondrial content and ramp up antioxidant enzymes with age, while short-lived strains show early mitochondrial loss and apoptotic signaling.

Research Paper
Oct 7, 2026 0
RhoA Signaling in the Heart Protects Against Cardiac Stress While Driving Fibrosis
Heart Health

RhoA Signaling in the Heart Protects Against Cardiac Stress While Driving Fibrosis

A new review reveals RhoA acts as a dual-edged signaling hub in the heart — shielding cardiomyocytes from ischemic damage while also promoting fibrosis.

Research Paper
Oct 7, 2026 0
One in Three High-Risk Outpatients Has CKD — and Most Go Undertreated
Metabolic Health

One in Three High-Risk Outpatients Has CKD — and Most Go Undertreated

A Central European tertiary care study finds CKD in 32.5% of at-risk outpatients, with a major gap in renoprotective therapy use.

Research Paper
Oct 7, 2026 0
Rapamycin Blocks Airway Scarring After Injury by Targeting mTORC1
Regenerative Medicine

Rapamycin Blocks Airway Scarring After Injury by Targeting mTORC1

New mouse model research shows mTORC1 drives tracheal scarring post-injury, and early rapamycin treatment can prevent it.

Research Paper
Oct 7, 2026 0
A Multimodal Sleep Intervention Cuts Insomnia and Depression in Army Recruits
Sleep & Recovery

A Multimodal Sleep Intervention Cuts Insomnia and Depression in Army Recruits

A structured sleep program gave soldiers 30 extra minutes of sleep nightly and slashed insomnia, stress, and depressive symptoms during grueling basic training.

Research Paper
Oct 7, 2026 0
Gut Microbiome Remodeling Through Diet Boosts Cancer Immunotherapy in Obesity
Gut & Microbiome

Gut Microbiome Remodeling Through Diet Boosts Cancer Immunotherapy in Obesity

Diet-driven changes to the gut microbiome may explain why obesity enhances immune checkpoint blockade and open new immunotherapy optimization strategies.

Research Paper
Oct 7, 2026 0
Belimumab Holds Lupus Organ Damage Near Zero Over 8 Years in Landmark Long-Term Study
Autoimmune & Arthritis

Belimumab Holds Lupus Organ Damage Near Zero Over 8 Years in Landmark Long-Term Study

Pooled data from 1,299 SLE patients show belimumab nearly halts organ damage accrual and slashes steroid use over 8 years.

Research Paper
Oct 6, 2026 0
Osteoporosis Is Multiple Diseases — and Treatment Should Match the Subtype
Hormones

Osteoporosis Is Multiple Diseases — and Treatment Should Match the Subtype

A new review reframes osteoporosis as a heterogeneous syndrome with distinct subtypes, each demanding personalized therapy strategies.

Review
Oct 6, 2026 0
Gut Microbiome Modifications Can Reverse Genetic Liver Disease Risk in PNPLA3 Carriers
Gut & Microbiome

Gut Microbiome Modifications Can Reverse Genetic Liver Disease Risk in PNPLA3 Carriers

A disrupted gut barrier amplifies fatty liver disease risk in people with the PNPLA3 gene variant — and targeted microbiome interventions can reverse it.

Research Paper
Oct 6, 2026 0
SS-31 Peptide Reverses Age-Related Oocyte Decline by Restoring Mitochondrial Function
Hormones

SS-31 Peptide Reverses Age-Related Oocyte Decline by Restoring Mitochondrial Function

A mitochondria-targeting peptide dramatically improves egg quality in aged mice, cutting aneuploidy and boosting embryo development rates.

Research Paper
Oct 5, 2026 0
Women Work Harder Cardiovascularly Than Men During HIFT and Kettlebell Training
Exercise & Fitness

Women Work Harder Cardiovascularly Than Men During HIFT and Kettlebell Training

New research finds women experience significantly higher heart rate and ventilatory load than men during the same high-intensity functional workouts.

Research Paper
Oct 4, 2026 0
New Gene-Mapping Tool Reveals How a Single Variant Drives Autoimmune Risk via mTOR
Autoimmune & Arthritis

New Gene-Mapping Tool Reveals How a Single Variant Drives Autoimmune Risk via mTOR

A nanoscale chromatin-mapping platform uncovers how a single noncoding variant creates a rogue DNA motif that silences a key mTOR-regulating gene, raising autoimmunity risk.

Research Paper
Oct 4, 2026 0
Multi-Omics Study Uncovers 28 Biomarkers and Drug Targets for Sleep Apnea
Sleep & Recovery

Multi-Omics Study Uncovers 28 Biomarkers and Drug Targets for Sleep Apnea

A large-scale genomic analysis identifies 28 molecular biomarkers for obstructive sleep apnea, revealing new drug targets and epigenetic mechanisms.

Research Paper
Oct 2, 2026 0
The Four-Pillar Framework for Getting Soccer Players Back to Peak Performance After ACL Surgery
Exercise & Fitness

The Four-Pillar Framework for Getting Soccer Players Back to Peak Performance After ACL Surgery

A new continuum model maps the full journey from ACL reconstruction to sustained match performance, targeting re-injury and career longevity.

Review
Oct 1, 2026 0

Our Sponsors

AhR as a Longevity Target: Crosstalk, Epigenetics, and Therapeutic FrontiersLongevity & AgingAdvanced

AhR as a Longevity Target: Crosstalk, Epigenetics, and Therapeutic Frontiers

Tutorial
Oct 7, 2026
AhR Signaling Pathways: From Ligand Binding to Longevity OutcomesLongevity & AgingIntermediate

AhR Signaling Pathways: From Ligand Binding to Longevity Outcomes

Tutorial
Oct 6, 2026
Your Cells Have a Pollution Sensor — And It Affects How You AgeLongevity & AgingBeginner

Your Cells Have a Pollution Sensor — And It Affects How You Age

Tutorial
Oct 5, 2026
Ceramide Signaling at the Molecular Frontier: Lipotoxic Mechanisms in Aging BiologyMetabolic HealthAdvanced

Ceramide Signaling at the Molecular Frontier: Lipotoxic Mechanisms in Aging Biology

Tutorial
Oct 4, 2026
Ceramide Signaling: How Toxic Lipids Hijack Your Cell's Control SystemsMetabolic HealthIntermediate

Ceramide Signaling: How Toxic Lipids Hijack Your Cell's Control Systems

Tutorial
Oct 3, 2026
When Fat Turns Toxic: Understanding Ceramides and Your Aging CellsMetabolic HealthBeginner

When Fat Turns Toxic: Understanding Ceramides and Your Aging Cells

Tutorial
Oct 2, 2026
Xenobiotic Metabolism at the Systems Level: Epigenomics, Interindividual Variation, and Therapeutic TargetingLongevity & AgingAdvanced

Xenobiotic Metabolism at the Systems Level: Epigenomics, Interindividual Variation, and Therapeutic Targeting

Tutorial
Oct 1, 2026
The Molecular Machinery of Detox: How Aging Rewires Your Xenobiotic DefenseLongevity & AgingIntermediate

The Molecular Machinery of Detox: How Aging Rewires Your Xenobiotic Defense

Tutorial
Sep 30, 2026
How Your Body Cleans House: Understanding Detox and AgingLongevity & AgingBeginner

How Your Body Cleans House: Understanding Detox and Aging

Tutorial
Sep 29, 2026
Zinc Metallostasis: Molecular Mechanisms, Senescence Networks, and Therapeutic FrontiersLongevity & AgingAdvanced

Zinc Metallostasis: Molecular Mechanisms, Senescence Networks, and Therapeutic Frontiers

Tutorial
Sep 28, 2026
Zinc Transporters, Zinc Fingers, and the Aging CellLongevity & AgingIntermediate

Zinc Transporters, Zinc Fingers, and the Aging Cell

Tutorial
Sep 27, 2026
Zinc: The Tiny Mineral With a Big Role in How You AgeLongevity & AgingBeginner

Zinc: The Tiny Mineral With a Big Role in How You Age

Tutorial
Sep 26, 2026
Lamins at the Frontier: Molecular Precision in Nuclear Envelope AgingLongevity & AgingAdvanced

Lamins at the Frontier: Molecular Precision in Nuclear Envelope Aging

Tutorial
Sep 25, 2026
Lamins Under the Microscope: Mechanisms of Nuclear Envelope DysfunctionLongevity & AgingIntermediate

Lamins Under the Microscope: Mechanisms of Nuclear Envelope Dysfunction

Tutorial
Sep 24, 2026
Your Cell's Control Room: How the Nuclear Envelope AgesLongevity & AgingBeginner

Your Cell's Control Room: How the Nuclear Envelope Ages

Tutorial
Sep 23, 2026

Recommended Products