20 articles
Intermittent expression of Yamanaka factors in hippocampal neurons reversed cognitive deficits and restored neural synchrony in a tauopathy mouse model.
Scientists demonstrate how brief activation of cellular reprogramming factors can rejuvenate aged organs and restore regenerative capacity safely.
Scientists discover how reprogramming factors rejuvenate eye cells and restore vision by activating a protective enzyme that clears toxic lipids.
A pharmacological cocktail transiently activates reprogramming genes in senescent endothelial cells, restoring function and improving blood flow in aged mice.
Korean researchers identify four rejuvenation factors that reduce senescence markers in aged cells — without triggering dangerous pluripotency programs.
Japanese researchers develop minimally invasive method to transform T cells into glutamatergic neurons using just 5 factors.
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
A phenotypic screen of 20,000 molecules identified CN045, a CNS-penetrable compound that promotes myelin repair with potency exceeding thyroid hormone T3.
The father of induced pluripotent stem cells discusses regenerative medicine milestones and future therapeutic potential.
UCSF scientists screened 400 transcription factors and found four that reverse cellular aging hallmarks — one rejuvenated mouse livers in vivo.
Placental stem cell vesicles containing microRNAs reactivate aging neural cells through OSKM transcription factors.
Scientists developed targeted mRNA therapy that rejuvenates liver cells and reverses fibrosis in mice by temporarily reprogramming them.
Boosting lysosomal function via the mTOR/TFEB pathway cuts lipofuscin-like buildup by 30% in retinal cells, pointing toward early AMD therapy.
Comprehensive review reveals promising new drug targets and immunotherapy approaches for myelofibrosis beyond current JAK inhibitor limitations.
Tetramethylpyrazine targets mitofusin-2 to restore mitochondria-ER communication, blocking calcium overload and liver scarring.
A telomerase-derived peptide shows striking ability to reduce neuroinflammation and promote remyelination in a multiple sclerosis mouse model.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
Promising drug candidate 4-MU fails to demonstrate a clear mechanism or effective dosing for liver fibrosis, challenging its repurposing potential.
Revolutionary approach using Yamanaka factors shows promise for restoring youthful function to aging retinal cells and treating blindness.
Scientists identify Tβ4 as a neuroprotective factor that rescues neuronal loss and amyloid buildup in both human fAD organoids and 5xFAD mice.
