12 articles
Discover how four tiny proteins can turn back the clock on aging cells — and what this means for the future of medicine and longevity.
A pharmacological cocktail transiently activates reprogramming genes in senescent endothelial cells, restoring function and improving blood flow in aged mice.
Korean researchers identify four rejuvenation factors that reduce senescence markers in aged cells — without triggering dangerous pluripotency programs.
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Japanese researchers develop minimally invasive method to transform T cells into glutamatergic neurons using just 5 factors.
The father of induced pluripotent stem cells discusses regenerative medicine milestones and future therapeutic potential.
UCSF scientists screened 400 transcription factors and found four that reverse cellular aging hallmarks — one rejuvenated mouse livers in vivo.
Boosting lysosomal function via the mTOR/TFEB pathway cuts lipofuscin-like buildup by 30% in retinal cells, pointing toward early AMD therapy.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
Researchers identify methods to induce powerful regenerative cell clusters in mammals using temporary pluripotency factors.
