9,722 articles
Cardiovascular-kidney-metabolic syndrome affects nearly all US adults. A staged intervention model offers a roadmap from early risk to advanced disease.
PAI-1 emerges as a master immune-aging checkpoint linking senescence, fibrosis, and cancer — and TM5614 is already in human trials.
A Phase III trial tests whether blocking PAI-1 with TM5614 can restore immunotherapy sensitivity in anti-PD-1-refractory melanoma patients.
A new mouse study reveals that PAI-1 secreted by infiltrating macrophages blocks efferocytosis, sustaining inflammation and impairing tissue repair.
A common blood pressure drug suppresses a key fibrosis pathway, offering new hope for cancer patients suffering radiation-induced lung damage.
A curated overview of the most significant findings presented at the 2026 Alzheimer's Association International Conference, spanning prevention to treatment.
A 90-day randomized trial shows a traditional Chinese herb reshapes gut bacteria and reduces markers of T-cell immune exhaustion in adults over 60.
A routine creatinine-to-cystatin C ratio predicts mortality in 1,000+ centenarians, offering a cheap, accessible muscle-health biomarker.
Bifidobacterium pseudocatenulatum transforms hesperidin into hesperetin, activating a longevity gene and reversing metabolic aging in mice.
Rapamycin reprogrammed the immune landscape in aged atherosclerotic mice, reducing plaque macrophages, inflammatory T cells, and senescent immune cells.
Scientists rejuvenate aging hearts by transplanting healthy mitochondria, restoring a broken cellular recycling pathway via the HIF-3α-BNIP3 axis.
A 12-week RCT finds older adults on vegetarian and omnivorous diets both gained muscle with resistance training, but vegetarians consumed significantly less protein.
