Lipid Nanoparticles Enable Direct In Vivo Gene Editing of Blood Stem Cells
Antibody-targeted lipid nanoparticles edit hematopoietic stem cells directly in living organisms, bypassing the complex ex vivo manufacturing process.
Stem cell therapies, regenerative medicine, tissue engineering, and cellular reprogramming
338 articles
Antibody-targeted lipid nanoparticles edit hematopoietic stem cells directly in living organisms, bypassing the complex ex vivo manufacturing process.
A next-generation gene editing approach fixes a severe immunodeficiency in blood stem cells with high precision and minimal off-target effects.
Converting blood cells directly into neural stem cells triggers dramatic epigenetic de-aging, resetting biological age to as little as 5% of donor age.
A single compound reverses muscle-disuse bone atrophy in lab and animal models, offering hope for astronauts and bedridden patients.
A jellyfish study reveals that aging depletes stem cells and blocks blastema formation, suggesting regeneration decline is a universal feature of aging.
Liver-targeted OSKM mRNA delivery induces regenerative progenitor cells and enhances recovery from acute liver injury in mice.
New nanomedicine strategies reprogram dormant cells and modulate immunity to unlock the body's hidden regenerative potential.
Scientists identify a fetal-restricted gene that, when reactivated, restores the transplant potential of aged blood stem cells expanded in the lab.
Senescent cells disrupt skin repair with age — and emerging senotherapeutics may restore regenerative capacity in aged and diseased tissue.
A deep learning model trained on 3D chromatin images can distinguish young from aged blood stem cells — and flag when epigenetic drugs reverse that aging signature.
What red and near-infrared light is proposed to do in tissue, which indications rest on guidelines or randomized trials and which are still speculative, and how to judge whether a consumer panel delivers anything close to what a trial used.
Photobiomodulation plus exosomes, PRP, and growth factors may reverse skin aging by boosting collagen, elastin, and mitochondrial energy.