Autoimmune disorders, rheumatoid arthritis, systemic inflammation, and immune dysregulation
390 articles
A long noncoding RNA found in blood shows strong diagnostic accuracy for MS, potentially offering a simpler, earlier detection tool.
A new review reveals how TRPV1 ion channels govern skin homeostasis, inflammation, and aging — and how targeting them could slow skin deterioration.
A lipid nanoparticle mRNA drug wiped out disease-causing B cells and restored platelets in refractory autoimmune patients — with no cytokine storm.
How immune function changes with age, why chronic sterile inflammation reinforces that decline, which immune measurements are worth ordering in ordinary practice, and which interventions have real evidence behind them.
How self-tolerance is enforced and how it fails, why an HLA risk genotype is not a prediction, and how to use — and not misuse — autoantibodies in the years before symptoms appear.
A phase 1 trial of A-319, a CD3×CD19 bispecific T cell engager, achieved 60% remission in lupus patients with a favorable safety profile.
A single in vivo CAR T-cell infusion (JY231) dramatically improved ambulation in a patient with progressive MS, shown in NEJM clinical video.
Starting anti-TNF therapy at diagnosis rather than stepping up later dramatically reduces surgery, hospitalization, and disease progression in Crohn's disease.
Cytokines, checkpoint inhibitors, CAR-T cells, and vaccines are being tested to rescue failing immune defenses against life-threatening Candida infections.
GLP-1 receptor agonists may directly combat inflammation in rheumatoid arthritis, lupus, and psoriasis, independent of weight loss.
A 20-year prospective study of nearly 16,000 adults finds high Mediterranean Diet adherence associated with a 47% lower risk of developing rheumatoid arthritis.
A clinical guide to reading HLA results: which alleles change prescribing today, why a coeliac-permissive type is not a diagnosis, and when a genome-derived HLA call must be confirmed before you act on it.
