Longevity & AgingTau Global Conference 2025 maps new routes to understanding and treating tauopathies
The Tau Global Conference 2025 in London merged three major tau meetings. Researchers from academia, industry, government and philanthropy reviewed progress in tauopathies such as Alzheimer's disease, PSP, CBD and frontotemporal dementia. Key themes included lysosomal enzymes that break down tau, and mutations that may slow that clearance. Tau also appears to spread along brain networks, with amyloid-β and microglia accelerating it. New models, including directly reprogrammed human neurons, knock-in mice and live human brain slices, are sharpening mechanistic work. Risk modifiers discussed included socioeconomic deprivation, sleep disruption and endemic parkinsonism clusters. The report stresses biomarker-informed trials and global, inclusive collaboration. It is a conference summary, not a primary study, so findings are preliminary and vary in evidence strength.
