Longevity & AgingSmart Microspheres Reverse Cartilage Aging by Hijacking Cellular Receptors
Researchers developed antibody-coated liposomes loaded with the DNA-repair gene Sirt6, designed to cluster urokinase receptors on senescent chondrocytes and boost cellular drug uptake. Senescent cells normally resist drug delivery because aging membranes impair endocytosis. By targeting overexpressed uPAR receptors, the system achieved 1.7–2x higher uptake in lab studies and 1.5x higher uptake in live animals. Encapsulating the liposomes in hyaluronic acid hydrogel microspheres extended their retention in joints. In osteoarthritis mice, the treatment reduced senescence markers, preserved cartilage proteins collagen II and aggrecan, and restored normal gait — suggesting a viable strategy for treating age-related joint degeneration.
