Longevity & AgingSkinspan: A Tiered Roadmap for Evidence-Based Skin Longevity
A 2025 review in the Journal of Cosmetic Dermatology introduces 'skinspan' — the period during which skin maintains youthful, healthy function — as a formal clinical concept grounded in geroscience. The authors map four molecular hallmarks of skin aging (genomic instability, mitochondrial dysfunction, cellular senescence, and proteostasis decline) to a tiered intervention algorithm. First-line strategies include broad-spectrum sun protection, topical retinoids, and antioxidants like vitamin C. Second-line options encompass laser and energy-based devices. Emerging third-line adjuncts — sirtuins, NAD+ precursors, stem cell therapies, and melatonin — show promise but await stronger RCT evidence. Lifestyle pillars including diet, sleep, exercise, and smoking cessation are integrated throughout.
