Longevity & AgingSIRT1 Decline Drives Aging and How Activating It Could Turn the Clock Back
SIRT1, a NAD+-dependent enzyme, plays a central role in regulating aging at the cellular level. As we age, SIRT1 expression drops significantly, contributing to mitochondrial dysfunction, oxidative stress, and cellular senescence — hallmarks of biological aging. This review consolidates recent research showing that boosting SIRT1 activity can counteract these damaging processes and slow the progression of age-related diseases. The authors examine evidence from multiple experimental models and highlight both the promise of SIRT1 activation as a therapeutic target and the current gaps in knowledge that must be addressed before clinical applications can be realized.
