Longevity & AgingSingle Gut Procedure Helps Patients Keep Off Weight After Stopping GLP-1 Drugs
A new endoscopic procedure called Revita, developed by Fractyl Health, may help people keep off weight after they stop taking GLP-1 drugs like Ozempic or Wegovy. In a small open-label study, participants who had lost at least 15% of their body weight on GLP-1 therapy retained about 78% of that weight loss one year after stopping the drug — following just one Revita procedure. Notably, one in three patients continued losing weight even after discontinuing GLP-1s. Blood sugar control also remained largely stable, which is significant since stopping GLP-1s often triggers metabolic backsliding. The procedure works by remodeling the lining of the duodenum and carries FDA Breakthrough Device designation. Larger randomized trial data are expected later in 2026.
