NAD+ supplements attract attention for healthy aging, but this review finds they are not an established treatment for age-related muscle loss. NAD+ helps cells manage energy and supports enzymes involved in muscle maintenance. Although animal studies suggest benefits from restoring it, the review reports that recent pooled analyses found no significant improvement in muscle mass or strength with nicotinamide riboside or nicotinamide mononucleotide in adults older than 60. Some mouse experiments also challenge the idea that low NAD+ necessarily causes muscle decline. Exercise supports the body's NAD+ recycling system, making combinations with targeted supplements worth investigating, but their benefits remain unproven. The practical message is to prioritize exercise rather than expect supplements alone to reverse muscle loss. This summary is based only on the abstract.
