Longevity & AgingMapping Every Drug Approach to Skin Aging — A 47-Intervention Review
Skin aging is driven by interlocking processes — oxidative stress, mitochondrial dysfunction, collagen breakdown, and inflammation — that are often studied in isolation. This review synthesized 91 reports covering 47 different anti-aging intervention classes, drawn from a search of nearly 8,000 records. The authors found that oxidative stress is not just a starting trigger but a central hub that both amplifies and is reinforced by other aging mechanisms, forming self-perpetuating feedback loops. Promising interventions targeting this hub showed consistent results in cell and animal models. The review also proposes a forward-looking framework combining skin organoid models, nanoparticle drug delivery, and AI-driven target screening to accelerate development of multi-mechanism anti-aging therapies and move them toward clinical use.
