Longevity & AgingLow Insulin Sensitivity Score Accelerates Aging and Raises Death Risk in Heart-Kidney-Metabolic Disease
Researchers analyzed 4,826 U.S. adults with cardiovascular-kidney-metabolic (CKM) syndrome using NHANES data and validated findings in a Chinese cohort. They found that lower estimated glucose disposal rate (eGDR), a surrogate for insulin resistance calculated from waist circumference, blood pressure, and HbA1c, was independently associated with faster biological aging and higher all-cause and cardiovascular mortality. Each unit increase in eGDR reduced all-cause death risk by 10% and cardiovascular death risk by 13%. Crucially, accelerated phenotypic aging mediated roughly 24% of eGDR's effect on all-cause mortality, suggesting insulin resistance drives mortality partly through accelerating aging biology. Machine learning confirmed eGDR's strong predictive value.
