Longevity & AgingDXA Unlocks Hidden Body Composition Dangers in Male Hypogonadism
Male hypogonadism drives significant body composition changes—reduced lean mass, increased visceral fat, and bone loss—forming a syndrome called osteosarcopenic obesity. This 2026 review from Italian endocrinology centers examines the pathophysiology behind these changes, focusing on the disrupted crosstalk among bone, muscle, and adipose tissue via osteokines, myokines, and adipokines. Dual-energy X-ray absorptiometry (DXA) is positioned as the gold standard for assessing these changes clinically. The authors evaluate evidence across specific hypogonadal conditions—Klinefelter syndrome, Kallmann syndrome, androgen deprivation therapy, HIV infection, and transgender care—providing practical frameworks for integrating DXA into routine endocrine practice and monitoring testosterone replacement therapy outcomes.
