Brain HealthBrain Fluid Proteins Track Early Alzheimer's Changes Before Memory Problems
Researchers studied three proteins that help cells handle fats and debris in older adults with normal memory but elevated family risk of Alzheimer's disease. Higher levels of these proteins in fluid surrounding the brain were strongly associated with markers of changes at nerve cell connections. One protein, SCARB2, showed the strongest relationships. The proteins were more closely linked to tau, a protein involved in Alzheimer's disease, than to amyloid markers. Starting protein levels also correlated with rising levels of an Alzheimer's-related form of tau over up to 12 years. Analyses of donated brain tissue added evidence linking these proteins to cholesterol processing and immune activity. These findings suggest research targets, not proven treatments or screening tests. The study cannot establish cause and effect, and this summary relies on the abstract only.
