270 articles
Go beyond the basics and explore the biochemical machinery of vitamin B12 — how it's absorbed, converted, and used by neurons, and what breaks down in the aging brain.
How self-tolerance is enforced and how it fails, why an HLA risk genotype is not a prediction, and how to use — and not misuse — autoantibodies in the years before symptoms appear.
Discover how vitamin B12 keeps your nervous system healthy, why older adults are at higher risk of deficiency, and simple steps to protect your brain as you age.
A clinical account of where cancer can actually be interrupted — germline syndromes that change management now, the metabolic and inflammatory contribution, and the hard line between screens with mortality data and screens with detection data only.
Master the cutting-edge molecular science of TGF-β-driven fibrosis — from epigenetic reprogramming and mechanotransduction to next-generation therapeutic strategies targeting specific pathway nodes in aging tissue.
A sequenced account of the advanced longevity workup — genome, blood, imaging, function, microbiome, proteomics, liquid biopsy — with a stated confidence on every element and a method for turning fifty abnormal values into one first action.
A clinical walkthrough of the Alzheimer's cascade, APOE ε4 counseling, the plasma biomarkers that made pre-symptomatic detection real, and the risk-reduction plan the evidence actually supports — plus the Parkinson's prodrome you can ask about in a routine history.
Go beyond the basics and explore the precise molecular machinery that drives TGF-β-mediated fibrosis in aging — from receptor activation to Smad cascades, myofibroblast transformation, and emerging therapeutic targets.
A clinical framework for atherosclerosis as lifetime particle exposure rather than a ten-year risk percentage — how to combine apoB, Lp(a), coronary imaging and inherited risk into a decision about when to start treating, and how to explain a 'normal' lipid panel that isn't reassuring.
Discover how your body's own repair system can backfire with age, turning helpful healing signals into a slow build-up of scar tissue that stiffens organs and drives aging.
Type 2 diabetes is the late visible stage of a storage problem that begins years earlier. How to detect metabolic dysfunction while fasting glucose and HbA1c are still normal, how to stage the liver without a biopsy, and how to sequence the response.
Explore the advanced molecular architecture of purinergic stress signaling — from transcriptional reprogramming and metabolic crosstalk to emerging therapeutic strategies targeting CD38, P2X7, and the ectonucleotidase axis in aging.
