Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
6,763 articles
A new Nature Aging review identifies the distinct molecular signatures that define cellular senescence, opening doors to better senolytics and aging biomarkers.
Perimenopausal women show measurably lower brain creatine than younger adults, with regional deficits tied to concentration difficulties and estradiol drops.
FGF21 activates the Nrf2/GPX4 pathway to suppress ferroptosis after TBI, cutting oxidative damage and improving neurological recovery in mice.
A mouse study overturns the assumption that liver-derived FGF21 drives fasting metabolism, revealing its true role: directing protein appetite after food deprivation.
A triple-blind RCT found 200 mcg daily organic selenium significantly reduced endometrioma size and all pain types versus placebo over 3 months.
A comprehensive immune and molecular profiling study links T-cell aging signatures to silent carotid plaques in fit adults over 60.
A clinical case reveals how combining newer agents like finerenone, SGLT2 inhibitors, and GLP-1 agonists can tame uncontrolled blood pressure in DKD.
A comprehensive review finds GLP-1 RAs cause 20–30% lean mass loss alongside fat loss, raising concerns for older adults and frailty risk.
Scientists identify OTUD1 as a critical driver of microglial inflammation in Alzheimer's disease, revealing a novel therapeutic target.
New research reveals how pregnancy elevates adenosine levels, creating immunosuppressive neutrophils that accelerate tumor metastasis.
A multi-dataset single-cell atlas reveals an inflammatory, quiescent stem cell subpopulation that grows with age—a potential anti-aging target.
Airway immune cells package mitochondria into tiny vesicles that hijack T cells, fueling the chronic inflammation defining asthma.
