4,686 articles in this topic
A new study identifies Traf6 as a master regulator of inflammatory senescence in bone marrow stem cells, opening a targeted path to treat age-related osteoporosis.
A newly discovered molecular switch pushes aging bone marrow stem cells to make fat instead of bone, accelerating osteoporosis.
A new review reveals how Chinese herbal medicine induces cancer cell senescence via telomere shortening, DNA damage, and SASP regulation.
Scientists identify a novel disease-associated radial glia-like cell population in progressive MS brains with epigenetically dysregulated interferon signaling.
Losing progranulin accelerates vascular senescence, inflammation, and fibrosis—even in young adult mice—linking this protein to early cardiovascular aging.
A mouse study finds that blocking activin receptors strengthens trabecular bone, though high-fat diet obesity blunts the effect.
A comprehensive review reveals how endocrine dysfunction fuels the dangerous combination of muscle loss and fat gain, with implications for treatment.
Exosomes harvested from hyper-muscular mice counteract dexamethasone-induced atrophy, pointing to a novel cell-free therapy for sarcopenia.
Fibroblast-derived exosomes change with age, altering how keratinocytes differentiate — revealing a key mechanism in skin aging.
Scientists packaged the full telomerase enzyme into extracellular vesicles and reversed multiple hallmarks of aging in aged mice.
Irisin activates the AMPK-Beclin1 pathway to rescue blocked autophagy and reduce inflammation in cigarette smoke and bacterial infection models.
Scientists uncover how GPR107 stabilizes BECN1 to fuel secretory autophagy, keratinocyte proliferation, and chronic skin inflammation in psoriasis.
