129 artigos
Domine os mecanismos moleculares precisos por trás dos danos causados pela radiação cósmica e aprenda estratégias dietéticas baseadas em evidências, com doses específicas, que vão muito além dos conselhos básicos sobre antioxidantes.
How food, especially protein, switches the body toward growth and how fasting and exercise switch it toward cellular maintenance. Covers what the human evidence shows, why muscle wins in the older sarcopenic patient, and what is and is not known about rapamycin and metformin.
What a senescent cell is, why it protects before it harms, and how a small number of them drive tissue disease. Also what the senolytic trials have and have not shown, and how to counsel a patient who wants to start a protocol.
Um mergulho mecanicista profundo nas cascatas de sinalização, reprogramação epigenética e ciência translacional por trás da parabiose — das controvérsias sobre o GDF11 aos ensaios clínicos com plasma.
How the intestinal barrier fails and drives systemic inflammation, which stool and microbiome findings warrant action today, how the interventions rank by evidence, and the drug–microbiome interactions to anticipate.
How the adaptive immune system loses capacity with age, how chronic sterile inflammation feeds that loss, and how to read hs-CRP, the CD4:CD8 ratio and CMV serology. Interventions are ranked by the evidence behind them.
Protein and metabolite measurements report what the body is doing now, not what it inherited. This tutorial covers what single proteins already decide in clinic, what broad protein panels and organ-age signals can and cannot claim, why metabolomics is hard to read, and why all of it is built for serial tracking rather than a single snapshot.
Uma investigação mecanística aprofundada sobre como a rapamicina e os rapalogs de próxima geração modulam as vias do envelhecimento — da cinética de ligação alostérica ao design de ensaios clínicos e aos emergentes inibidores bi-estéricos.
How methylation clocks are built, why the training target sets what a result means, and why measurement noise matters more than any other point when a patient reports that their biological age has fallen.
How the integrative hallmarks of aging produce the frailty and multimorbidity seen in clinic, how to measure them with a dynamometer, a stopwatch and a routine blood panel, and why structured training moves more of them at once than any drug or supplement.
Three aging hallmarks begin as protective responses and become harmful when they stay switched on. This tutorial covers what can be measured in a patient today and how far the human evidence for rapamycin, metformin, NAD precursors and senolytics actually goes.
Uma exploração mecanicista aprofundada de como a deficiência de B12 remodela o epigenoma do cérebro que envelhece, alimenta a neuroinflamação e exige estratégias de correção individualizadas que vão além dos protocolos de dosagem padrão.
