129 artigos
Explore a ciência de ponta sobre como o envelhecimento desmantela as defesas xenobióticas nos níveis genômico, epigenômico e sistêmico — e quais intervenções emergentes podem restaurá-las.
Menopausal hormone therapy after the WHI reinterpretation, a proper workup for low testosterone, subclinical thyroid results, and growth hormone, organized around one line: whether therapy restores a physiological range or goes beyond it.
How GLP-1 and dual-agonist drugs work, which cardiometabolic outcomes they and the other metabolic pillars have demonstrated, and how to manage lean-mass loss, gastrointestinal effects, peri-procedural risk and the weight regain that follows stopping.
What red and near-infrared light is proposed to do in tissue, which indications rest on guidelines or randomized trials and which are still speculative, and how to judge whether a consumer panel delivers anything close to what a trial used.
Uma exploração mecanicista aprofundada de como a disregulação do zinco impulsiona o envelhecimento no nível molecular — da cinética de transportadores e química redox de dedos de zinco à sinalização de senescência e estratégias terapêuticas emergentes.
A clinical guide to what is injected under the stem cell label, why the cells mostly act through what they secrete rather than by becoming new tissue, where the approved therapies and controlled trials actually sit, and how to judge a clinic's claims.
Where approved peptide medicines, off-label growth hormone secretagogues and unapproved tissue-repair peptides sit on the evidence spectrum, what the regulatory position means for sourcing, and how to answer a patient who asks about them.
How hyperbaric oxygen works, which indications rest on real evidence, what the telomere and cognition trials did and did not show, and how to counsel a patient weighing a 60-session course or a home soft chamber.
Um tour mecanístico aprofundado sobre como a biologia das laminas interage com a resposta ao dano ao DNA, a arquitetura da cromatina, a inflamação e o direcionamento terapêutico — o capítulo final avançado da série sobre envelhecimento do envelope nuclear.
What the sauna cohorts and cold-exposure trials actually tested, why a cold plunge after lifting works against the session, and who should do neither.
NAD+ declines with age mainly because consumption rises, not because production fails. This tutorial covers what precursor trials have and have not demonstrated, why IV NAD+ adds cost without a shown advantage, and what raises NAD+ without a purchase.
Why there is no useful blood test for mitochondrial capacity but there is an excellent functional one, how to recognize inherited mitochondrial disease and refer it, and how the interventions for acquired dysfunction rank against each other, with aerobic training far ahead of every supplement.
