108 artigos
A clinical account of heat, cold and exercise as dose-dependent stressors — what the observational sauna cohorts can and cannot support, why cold immersion after lifting works against the session, and who should be doing neither.
Why the NAD+ pool falls with age is a consumption problem, not a production failure — and why that reframes every question about NR, NMN and intravenous NAD. What the human trials actually measured, what they did not, and how to answer the patient holding the bottle.
A practical account of what mitochondrial function means clinically — why there is no blood test for capacity but an excellent functional one, how to recognize inherited mitochondrial disease and refer, and an honest evidence ranking of the interventions patients ask about.
Domine os mecanismos moleculares precisos por trás dos danos causados pela radiação cósmica e aprenda estratégias dietéticas baseadas em evidências, com doses específicas, que vão muito além dos conselhos básicos sobre antioxidantes.
A clinical account of the nutrient-sensing trade-off — what actually induces cellular clean-up in humans rather than in mice, why muscle wins the argument in an older patient, and where the rapamycin and metformin evidence genuinely stops.
What a senescent cell is, how a small population drives systemic inflammation, and an honest account of senolytic human data — early-phase, mechanistic, and short of any outcome a patient cares about.
Um mergulho mecanicista profundo nas cascatas de sinalização, reprogramação epigenética e ciência translacional por trás da parabiose — das controvérsias sobre o GDF11 aos ensaios clínicos com plasma.
A clinician's guide to reading gut microbiome results honestly — how barrier failure becomes systemic inflammation, why fiber and fermented foods outrank every supplement on trial evidence, and which drug–microbiome interactions change prescribing.
How immune function changes with age, why chronic sterile inflammation reinforces that decline, which immune measurements are worth ordering in ordinary practice, and which interventions have real evidence behind them.
A clinical guide to protein and metabolite measurement — why these layers report present state rather than inherited risk, what broad panels can and cannot support, and how to judge an organ-age or metabolomic result you did not order.
Uma investigação mecanística aprofundada sobre como a rapamicina e os rapalogs de próxima geração modulam as vias do envelhecimento — da cinética de ligação alostérica ao design de ensaios clínicos e aos emergentes inibidores bi-estéricos.
A clinical guide to interpreting biological-age and pace-of-aging results: what the epigenome is, what each generation of clock was trained to predict, why repeat testing of the same sample can differ by years, and how to counsel a patient who wants to buy one.
