Evidence-based supplements, vitamins, minerals, nootropics, and longevity interventions
295 articles
Why the NAD+ pool falls with age is a consumption problem, not a production failure — and why that reframes every question about NR, NMN and intravenous NAD. What the human trials actually measured, what they did not, and how to answer the patient holding the bottle.
Dr. Eric Berg breaks down the multi-system effects of daily turmeric consumption, from neurogenesis and neurotransmitter support to gut microbiome diversity and liver health.
A NAMPT-activating compound preserved grip strength and boosted muscle fiber size in two-year-old mice, pointing to a new NAD+ strategy against sarcopenia.
The leucine metabolite HMB improved grip strength, muscle fiber size, and mitochondrial respiration in a severe mouse model of Duchenne muscular dystrophy.
Combining nicotinic acid with semaglutide restores NAD+/SIRT1 signaling and curbs fibrotic damage in a rat model of pulmonary fibrosis.
A new review finds Schisandra chinensis extracts combat cellular senescence via antioxidant, mitochondrial, and anti-inflammatory pathways at once.
A comprehensive product review finds NR and NMN both raise NAD+ in humans, but product quality varies wildly — only 26 of 70 NR supplements met label claims.
A Wayne State University trial tests a multi-ingredient skin cream — including peptides, hyaluronic acid, and CoQ10 — for measurable wrinkle and roughness reduction.
Dr. Brad Stanfield examines the clinical evidence on vitamin K2 and coronary artery calcification — and why the data hasn't translated into cardiology practice.
Thomas DeLauer breaks down how common multivitamin formulations contain nutrient forms and pairings that may actually impair absorption and health outcomes.
Fetal hypoxia slashes litter sizes by 58% through oocyte oxidative stress — and NMN supplementation partially reverses the damage.
Spermidine activates AMPK to suppress a deadly form of cell death (necroptosis) in sepsis-induced acute lung injury, improving survival in rats.
