39 articles in this topic
A practical account of what mitochondrial function means clinically — why there is no blood test for capacity but an excellent functional one, how to recognize inherited mitochondrial disease and refer, and an honest evidence ranking of the interventions patients ask about.
Type 2 diabetes is the late visible stage of a storage problem that begins years earlier. How to detect metabolic dysfunction while fasting glucose and HbA1c are still normal, how to stage the liver without a biopsy, and how to sequence the response.
Dive deep into the molecular machinery underlying lactate's role in longevity — from HCAR1 receptor pharmacology and lactylation stoichiometry to inter-organ metabolic circuits and clinical translation strategies.
Go beyond the basics and explore how lactate activates AMPK, modulates gene expression through lactylation, and coordinates inter-organ communication to promote metabolic resilience and healthy aging.
Discover how lactate — once blamed for muscle soreness — is actually a powerful signaling molecule that may hold the key to metabolic health and longevity.
A deep mechanistic exploration of how glycolytic enzyme isoform switching, oncometabolite accumulation, and NAD+/redox imbalance drive metabolic aging — and the emerging interventions targeting these nodes.
Go beyond the basics to explore how glycolysis pathways, enzyme regulation, and mitochondrial crosstalk determine your metabolic flexibility — and how aging disrupts each step.
Discover how your body converts food into fuel, why this process changes with age, and simple habits that keep your metabolism youthful and flexible.
Dissect the precise molecular machinery through which BHB modulates epigenetic regulators, inflammatory cascades, and metabolic checkpoints — and how these converge on hallmarks of aging.
Go beyond ketones as fuel — explore the molecular conversations they start inside your cells, from HDAC inhibition to mTOR suppression, and why these pathways matter for healthy aging.
Discover how ketone bodies — produced during fasting or low-carb eating — act as powerful signals that may slow aging and boost metabolic health.
Master the molecular architecture of kynurenine pathway dysregulation — from transcriptional control of IDO1 to NMDA-mediated excitotoxicity, NAD+ depletion, and emerging therapeutic targets at the frontier of longevity medicine.
